7-ethyl-10-hydroxycamptothecin
As of the edition of 20 October 2026, 7-ethyl-10-hydroxycamptothecin is a small molecule: stopped in 2019; acts on TOP1.
Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.
The drug
- Status
- Stopped, 2019
- Kind
- Small molecule
- Registered trials
- 7, 1 stopped early
- Disease areas
- Cancer; Skin and connective tissue; Digestive system; Lungs and airways; Hormones; Pregnancy and women's health
US protection
No US approval on record.
With no US approval on record there are no listed US patents or exclusivities.
This is the US only.
Companies that need a new molecule because of this drug
1 company on route B and 1 company on route A because of this drug.
Companies on route B for this drug
In the product1 company is on route B because of 7-ethyl-10-hydroxycamptothecin.
See the 1 company on route B for this drug, with the facts behind eachRequest access. Nothing is shown until you do.
Companies on route A for this drug
In the product1 company is on route A because of 7-ethyl-10-hydroxycamptothecin.
See the 1 company on route A for this drug, with the facts behind eachRequest access. Nothing is shown until you do.
Target
| Gene | Protein | UniProt |
|---|---|---|
| TOP1 | DNA topoisomerase 1 | P11387 |
Registered trials
| Phase | Trials | Completed | Active | Stopped early |
|---|---|---|---|---|
| Phase 1 | 5 | 4 | 0 | 1 |
| Phase 2 | 2 | 2 | 0 | 0 |
| All trials | 7 |
Who ran its trials
| Company | Role | Years |
|---|---|---|
| Nippon Kayaku | Lead sponsor of trials | 2007 to now |
| Intezyne Technologies | Lead sponsor of trials | 2017 to now |
| SN BioScience | Lead sponsor of trials | 2020 to now |