Drug

Begacestat

As of the edition of 20 October 2026, Begacestat is a small molecule: went quiet in 2009; acts on PSEN1 and PSEN2.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Went quiet, 2009
Kind
Small molecule
Registered trials
4, 0 stopped early
Disease areas
Mental health; Nervous system

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

1 company-target row on route A because of this drug.

Companies on route A for this drug

In the product

1 company-target row is on route A because of Begacestat.

Targets

GeneProteinUniProt
PSEN1Presenilin-1P49768
PSEN2Presenilin-2P49810

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 14400
All trials4

Who ran its trials

CompanyRoleYears
PfizerLead sponsor of trials2007 to now