Drug

Padnarsertib

As of the edition of 20 October 2026, Padnarsertib is a small molecule: stopped in 2023; acts on NAMPT and PAK4.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Stopped, 2023
Kind
Small molecule
Registered trials
2, 2 stopped early
Disease areas
Cancer; Blood and lymph; Immune system; Skin and connective tissue

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

4 company-target rows on route A because of this drug.

Companies on route A for this drug

In the product

4 company-target rows are on route A because of Padnarsertib.

Targets

GeneProteinUniProt
PAK4Serine/threonine-protein kinase PAK 4O96013
NAMPTNicotinamide phosphoribosyltransferaseP43490

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 12002
All trials2

Who ran its trials

CompanyRoleYears
Karyopharm TherapeuticsLead sponsor of trials2016 to now
AntengeneLead sponsor of trials2020 to now