Phenprocoumon
As of the edition of 20 October 2026, Phenprocoumon is a small molecule: marketed, first approved in 1982 (US); acts on VKORC1; no US protection is listed.
Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.
The drug
- Status
- Marketed; latest approval 1982
- Kind
- Small molecule
- Brand name
- Liquamar
- First approved
- 1 January 1982 (US)
- Approvals on record
- 1 in 1 region
- Holder of the most recent approval
- Organon
- Registered trials
- 8, 2 stopped early
- Disease areas
- Heart and blood vessels; Lungs and airways
US protection
No US protection is listed.
The FDA registers list no drug-substance patent or exclusivity that counts for this drug.
This is the US only.
Target
| Gene | Protein | UniProt |
|---|---|---|
| VKORC1 | Vitamin K epoxide reductase complex subunit 1 | Q9BQB6 |
Registered trials
| Phase | Trials | Completed | Active | Stopped early |
|---|---|---|---|---|
| Phase not stated | 4 | 4 | 0 | 0 |
| Phase 4 | 4 | 2 | 0 | 2 |
| All trials | 8 |
Who has held its approvals
| Company | Role | Years |
|---|---|---|
| Organon | Acquired holder and Earlier holder | 2005 to now |