Pralidoxime
As of the edition of 20 October 2026, Pralidoxime is a small molecule: marketed, first approved in 1982 (US); acts on ACHE; no US protection is listed.
Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.
The drug
- Status
- Marketed; latest approval 1997
- Kind
- Small molecule
- Brand name
- Protopam Chloride
- First approved
- 1 January 1982 (US)
- Approvals on record
- 7 in 2 regions
- Holder of the most recent approval
- Pfizer; 6 holders in all
- Registered trials
- 4, 0 stopped early
- Disease areas
- Chemically induced
US protection
No US protection is listed.
The FDA registers list no drug-substance patent or exclusivity that counts for this drug.
This is the US only.
Companies that need a new molecule because of this drug
1 company on route B because of this drug.
Companies on route B for this drug
In the product1 company is on route B because of Pralidoxime.
See the 1 company on route B for this drug, with the facts behind eachRequest access. Nothing is shown until you do.
Target
| Gene | Protein | UniProt |
|---|---|---|
| ACHE | Acetylcholinesterase | P22303 |
Registered trials
| Phase | Trials | Completed | Active | Stopped early |
|---|---|---|---|---|
| Phase not stated | 3 | 2 | 1 | 0 |
| Phase 2 | 1 | 1 | 0 | 0 |
| All trials | 4 |
Who has held its approvals
| Company | Role | Years |
|---|---|---|
| Pfizer | Acquired holder and Earlier holder | 2003 to now |
| Baxter Healthcare | Acquired holder | 2003 to now |