Drug

Tacrine

As of the edition of 20 October 2026, Tacrine is a small molecule: marketed, first approved in 1993 (US); acts on ACHE and BCHE; no US protection is listed.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Marketed; latest approval 1993
Kind
Small molecule
Brand name
Cognex
First approved
9 September 1993 (US)
Approvals on record
4 in 1 region
Holder of the most recent approval
Shionogi
Registered trials
1, 1 stopped early
Disease areas
Chemically induced; Mental health

US protection

No US protection is listed.

The FDA registers list no drug-substance patent or exclusivity that counts for this drug.

This is the US only.

Companies that need a new molecule because of this drug

3 company-target rows on route B because of this drug.

Companies on route B for this drug

In the product

3 company-target rows are on route B because of Tacrine.

Targets

GeneProteinUniProt
BCHECholinesteraseP06276
ACHEAcetylcholinesteraseP22303

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 21001
All trials1

Who has held its approvals

CompanyRoleYears
ShionogiAcquired holder2011 to now
PfizerOriginator1993 to 2011