Bristol Myers Squibb at HMGCR
As of the edition of 20 October 2026, Bristol Myers Squibb is on route B at HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase), position 13 of 2,016 on that route, with a score of 0.778.
Sources: ClinicalTrials.gov, approval registers, ChEMBL, FDA Orange Book and Purple Book.
Route and score
Route B Score 0.778
Biology proven in humans0.89
How much the company cares0.88
Room, and a reason to act now0.60
Each part runs from 0 to 1; 0.5 is neutral, and an unknown fact counts as neutral.
What moved the score
Proof in humans at the target+0.294
Took its own drug far in human testing+0.225
Active at the target or its disease area recently+0.159
Trials at the target more often meet than miss their main endpoint+0.099
Few other companies active at the target+0.053
The company’s own follow-on drug+0.044
Why its own drug stopped0.000
The facts that decided the route
- Does the company have its own row at this target, rather than being counted under a drug that acts on many targets? The company has its own row at this target As of 20 October 2026.
- Has the company not been dissolved without a successor? The company still exists or has a successor As of 20 April 1998.
- Does the company have a marketed drug at this target? The company has a marketed drug at this target As of 31 October 1991.
- Does the company have no approved follow-on drug at this target? The company has no approved follow-on of its own As of 31 October 1991.
- Is the protein the drug acts on identified, and not only a complex it belongs to? The protein the drug acts on is on record, not only its complex As of 20 October 2026.
- Does a source say which of the drug's many targets it is designed for? The target the drug is designed for is established As of 20 October 2026.
The drugs
| Drug | Status | Furthest phase | Trials | US protection |
|---|---|---|---|---|
| Pravastatin | Marketed | Phase 4 | 109 | none listed |
The trials behind it
| Trial | Drug | Phase | Status | Years | Participants | Result |
|---|---|---|---|---|---|---|
| NCT05852769 | Pravastatin | Phase 1 | Completed | 2023 to 2023 | 18 | No results posted |
| NCT03131973 | Pravastatin | Phase 1 | Completed | 2017 to 2017 | 26 | No results posted |
| NCT02456844 | Pravastatin | Phase 1 | Completed | 2015 to 2015 | 24 | No results posted |
| NCT00529178 | Pravastatin | Phase 4 | Completed | 2002 to 2005 | 232 | No results posted |
| NCT00382460 | Pravastatin | Phase 4 | Completed | 2000 to 2003 | 4,000 | No results posted |