Probatebeta
Target

CFTR

Cystic fibrosis transmembrane conductance regulator

As of the edition of 20 October 2026, CFTR (cystic fibrosis transmembrane conductance regulator, UniProt P13569) has 20 drugs tested at it and 8 companies on the list, 4 on route A and 1 on route B.

Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.

The protein

UniProt
P13569
How well studied
Drug target: an approved drug acts on it
Where it sits in the cell
In more than one place
Solved structures
60
Disease areas
Digestive system; Lungs and airways; Inherited and neonatal; Infections; Immune system; Urinary and reproductive; Nutrition and metabolism; Skin and connective tissue
Registered trials of its drugs
201

Drugs at this target

StatusCount
Marketed6
Went quiet7
Stopped5
Status not established2
Total20
DrugStatusFurthest phaseUS protection
IvacaftorMarketedPhase 4Ends 2040
TezacaftorMarketedPhase 4none listed
ElexacaftorMarketedPhase 4none listed
LumacaftorMarketedPhase 4none listed
CrofelemerMarketedPhase 4none listed
VanzacaftorMarketedPhase 3none listed
GalicaftorStoppedPhase 2none listed
BamocaftorStoppedPhase 3none listed
GLPG-2737StoppedPhase 2none listed
IcenticaftorStoppedPhase 2none listed
NavocaftorStoppedPhase 2none listed
GLPG1837Went quietPhase 2none listed

12 of 20 drugs, the most tested first.

Companies at this target

Where the company standsCompanies
Route A4
Route B1
Engaged2
Undetermined1
Total on the list8
Three companies on route A or B, with the route only
CompanyRoute
NovartisRoute A
AbbVieRoute A
Napo PharmaceuticalsRoute B

The other 5 companies at CFTR

In the product

8 companies in all; 5 are not named here, and no score is.

See the 8 companies at CFTR, ranked, with the facts behind eachRequest access. Nothing is shown until you do.

More drugs at CFTR

Other targets in digestive system