Acamprosate
As of the edition of 20 October 2026, Acamprosate is a small molecule: marketed, first approved in 1987 (FR); acts on GRIN1, GRIN2A and GRIN2B and 4 more.
Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.
The drug
- Status
- Marketed; latest approval 2013
- Kind
- Small molecule
- Brand name
- Campral
- First approved
- 24 July 1987 (FR)
- Approvals on record
- 5 in 5 regions
- Holder of the most recent approval
- Nippon Shinyaku; 4 holders in all
- Registered trials
- 33, 9 stopped early
- Disease areas
- Mental health; Chemically induced; Nervous system; Inherited and neonatal; Nutrition and metabolism
US protection
No US approval on record.
With no US approval on record there are no listed US patents or exclusivities.
This is the US only.
Companies that need a new molecule because of this drug
10 company-target rows on route B because of this drug.
Companies on route B for this drug
In the product10 company-target rows are on route B because of Acamprosate.
See the 10 company-target rows on route B for this drug, with the facts behind eachRequest access. Nothing is shown until you do.
Targets
| Gene | Protein | UniProt |
|---|---|---|
| GRIN2D | Glutamate receptor ionotropic, NMDA 2D | O15399 |
| GRIN3B | Glutamate receptor ionotropic, NMDA 3B | O60391 |
| GRIN1 | Glutamate receptor ionotropic, NMDA 1 | Q05586 |
| GRIN2A | Glutamate receptor ionotropic, NMDA 2A | Q12879 |
| GRIN2B | Glutamate receptor ionotropic, NMDA 2B | Q13224 |
| GRIN2C | Glutamate receptor ionotropic, NMDA 2C | Q14957 |
| GRIN3A | Glutamate receptor ionotropic, NMDA 3A | Q8TCU5 |
Registered trials
| Phase | Trials | Completed | Active | Stopped early |
|---|---|---|---|---|
| Phase not stated | 5 | 2 | 0 | 3 |
| Phase 1 | 2 | 1 | 1 | 0 |
| Phase 2 | 11 | 8 | 0 | 3 |
| Phase 3 | 4 | 3 | 0 | 1 |
| Phase 4 | 11 | 8 | 0 | 2 |
| All trials | 33 |
Who has held its approvals
| Company | Role | Years |
|---|---|---|
| Actavis | Applicant and Lead sponsor of trials | 2004 to now |
| Nippon Shinyaku | Applicant | 2013 to now |