GRIN2D
Glutamate receptor ionotropic, NMDA 2D
As of the edition of 20 October 2026, GRIN2D (glutamate receptor ionotropic, NMDA 2D, UniProt O15399) has 17 drugs tested at it and 24 companies on the list, 4 on route A and 7 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- O15399
- How well studied
- Drug target: an approved drug acts on it
- Where it sits in the cell
- At a membrane
- Solved structures
- 13
- Disease areas
- Mental health; Nervous system; Cancer; Chemically induced; Injuries; Lungs and airways; Infections; Inherited and neonatal
- Registered trials of its drugs
- 1,356
Drugs at this target
| Status | Count |
|---|---|
| Marketed | 6 |
| Active | 1 |
| Went quiet | 4 |
| Stopped | 5 |
| Status not established | 1 |
| Total | 17 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Ketamine | Marketed | Phase 4 | none listed |
| Esketamine | Marketed | Phase 4 | Ends 2028 |
| Memantine | Marketed | Phase 4 | none listed |
| Amantadine | Marketed | Phase 4 | none listed |
| Acamprosate | Marketed | Phase 4 | none listed |
| Rapastinel | Stopped | Phase 3 | none listed |
| Neramexane | Stopped | Phase 3 | none listed |
| Lanicemine | Went quiet | Phase 2 | none listed |
| AV-101 | Stopped | Phase 3 | none listed |
| Apimostinel | Active | Phase 2 | none listed |
| Indantadol | Stopped | Phase 2 | none listed |
| CLE-100 | Status not established | Phase 2 | none listed |
12 of 17 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 4 |
| Route B | 7 |
| Engaged | 5 |
| Undetermined | 8 |
| Total on the list | 24 |
| Company | Route |
|---|---|
| Pfizer | Route B |
| AstraZeneca | Route A |
| Actavis | Route B |
The other 21 companies at GRIN2D
In the product24 companies in all; 21 are not named here, and no score is.
See the 24 companies at GRIN2D, ranked, with the facts behind eachRequest access. Nothing is shown until you do.