Drug

AZD-7451

As of the edition of 20 October 2026, AZD-7451 is a small molecule: went quiet in 2014; acts on NTRK1, NTRK2 and NTRK3.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Went quiet, 2014
Kind
Small molecule
Registered trials
1, 0 stopped early
Disease areas
Cancer; Nervous system

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Targets

GeneProteinUniProt
NTRK1High affinity nerve growth factor receptorP04629
NTRK3NT-3 growth factor receptorQ16288
NTRK2BDNF/NT-3 growth factors receptorQ16620

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 11100
All trials1