Benztropine
As of the edition of 20 October 2026, Benztropine is a small molecule: marketed, first approved in 1982 (US); acts on CHRM1; no US protection is listed.
Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.
The drug
- Status
- Marketed; latest approval 1999
- Kind
- Small molecule
- Brand name
- Cogentin
- First approved
- 1 January 1982 (US)
- Approvals on record
- 5 in 2 regions
- Holder of the most recent approval
- Omega Pharma; 3 holders in all
- Registered trials
- 8, 1 stopped early
- Disease areas
- Mental health; Bones, joints and muscles; Chemically induced; Immune system; Infections; Mouth and teeth
US protection
No US protection is listed.
The FDA registers list no drug-substance patent or exclusivity that counts for this drug.
This is the US only.
Companies that need a new molecule because of this drug
1 company on route B because of this drug.
Companies on route B for this drug
In the product1 company is on route B because of Benztropine.
See the 1 company on route B for this drug, with the facts behind eachRequest access. Nothing is shown until you do.
Target
| Gene | Protein | UniProt |
|---|---|---|
| CHRM1 | Muscarinic acetylcholine receptor M1 | P11229 |
Registered trials
| Phase | Trials | Completed | Active | Stopped early |
|---|---|---|---|---|
| Phase not stated | 1 | 0 | 0 | 1 |
| Phase 1 | 2 | 2 | 0 | 0 |
| Phase 2 | 3 | 3 | 0 | 0 |
| Phase 4 | 2 | 1 | 1 | 0 |
| All trials | 8 |
Who has held its approvals
| Company | Role | Years |
|---|---|---|
| Omega Pharma | Applicant | 1999 to now |
| Epic Pharma | Acquired holder | 2023 to now |
| Merck & Co. | Applicant |