Drug

Conivaptan

As of the edition of 20 October 2026, Conivaptan is a small molecule: marketed, first approved in 2005 (US); acts on AVPR1A and AVPR2; no US protection is listed.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Marketed; latest approval 2005
Kind
Small molecule
Brand name
Vaprisol
First approved
29 December 2005 (US)
Approvals on record
3 in 1 region
Holder of the most recent approval
Apotex; 2 holders in all
Registered trials
18, 6 stopped early
Disease areas
Nutrition and metabolism; Nervous system; Digestive system; Heart and blood vessels; Injuries; Pregnancy and women's health

US protection

No US protection is listed.

The FDA registers list no drug-substance patent or exclusivity that counts for this drug.

This is the US only.

Targets

GeneProteinUniProt
AVPR2Vasopressin V2 receptorP30518
AVPR1AVasopressin V1a receptorP37288

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase not stated1001
Phase 15500
Phase 23201
Phase 37403
Phase 42101
All trials18

Who has held its approvals

CompanyRoleYears
ApotexAcquired holder2026 to now
AstellasOriginator2005 to 2026