Ertugliflozin
As of the edition of 20 October 2026, Ertugliflozin is a small molecule: marketed, first approved in 2017 (US); acts on SLC5A2; US protection ends in 2031.
Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.
The drug
- Status
- Marketed; latest approval 2018
- Kind
- Small molecule
- Brand name
- Segluromet
- First approved
- 19 December 2017 (US)
- Approvals on record
- 13 in 3 regions
- Holder of the most recent approval
- Merck & Co.
- Registered trials
- 34, 3 stopped early
- Disease areas
- Nutrition and metabolism; Hormones; Heart and blood vessels; Pregnancy and women's health; Urinary and reproductive; Digestive system
US protection
US protection ends in 2031.
The last listed US drug-substance patent ends in 2031. The application that gives this date is held by Merck & Co..
This is the US only, and it is not the date generics or biosimilars can enter.
The exact date and the listings behind it
In the product10 listings count towards this date. The exact date and each listing are in the product.
See the exact date and the 10 listings behind itRequest access. Nothing is shown until you do.
Companies that need a new molecule because of this drug
1 company on route B because of this drug.
Companies on route B for this drug
In the product1 company is on route B because of Ertugliflozin.
See the 1 company on route B for this drug, with the facts behind eachRequest access. Nothing is shown until you do.
Target
| Gene | Protein | UniProt |
|---|---|---|
| SLC5A2 | Sodium/glucose cotransporter 2 | P31639 |
Registered trials
| Phase | Trials | Completed | Active | Stopped early |
|---|---|---|---|---|
| Phase not stated | 1 | 0 | 1 | 0 |
| Phase 1 | 11 | 10 | 1 | 0 |
| Phase 2 | 4 | 3 | 1 | 0 |
| Phase 3 | 12 | 11 | 0 | 0 |
| Phase 4 | 6 | 1 | 2 | 3 |
| All trials | 34 |
Who has held its approvals
| Company | Role | Years |
|---|---|---|
| Merck & Co. | Originator and Lead sponsor of trials | 2009 to now |