Drug

Indoximod

As of the edition of 20 October 2026, Indoximod is a small molecule: stopped in 2021; acts on MLST8, MTOR and RPTOR.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Stopped, 2021
Kind
Small molecule
Registered trials
16, 3 stopped early
Disease areas
Cancer; Skin and connective tissue; Nervous system; Digestive system; Hormones; Lungs and airways

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Targets

GeneProteinUniProt
MTORSerine/threonine-protein kinase mTORP42345
RPTORRegulatory-associated protein of mTORQ8N122
MLST8Target of rapamycin complex subunit LST8Q9BVC4

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase not stated1001
Phase 17511
Phase 28611
All trials16

Who ran its trials

CompanyRoleYears
NewLink GeneticsLead sponsor of trials2013 to now