Ipilimumab
As of the edition of 20 October 2026, Ipilimumab is an antibody: marketed, first approved in 2011 (US); acts on CTLA4; US protection ends in 2027.
Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.
The drug
- Status
- Marketed; latest approval 2015
- Kind
- Antibody
- Brand name
- Yervoy
- First approved
- 25 March 2011 (US)
- Approvals on record
- 15 in 5 regions
- Holder of the most recent approval
- Bristol Myers Squibb
- Registered trials
- 774, 145 stopped early
- Disease areas
- Cancer; Skin and connective tissue; Urinary and reproductive; Lungs and airways; Pregnancy and women's health; Digestive system
US protection
US protection ends in 2027.
The orphan exclusivity ends in 2027 (it covers one use only). The application that gives this date is held by Bristol Myers Squibb.
This is the US only, and it is not the date generics or biosimilars can enter.
The exact date and the listings behind it
In the product2 listings count towards this date. The exact date and each listing are in the product.
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Companies that need a new molecule because of this drug
1 company on route B because of this drug.
Companies on route B for this drug
In the product1 company is on route B because of Ipilimumab.
See the 1 company on route B for this drug, with the facts behind eachRequest access. Nothing is shown until you do.
Target
| Gene | Protein | UniProt |
|---|---|---|
| CTLA4 | Cytotoxic T-lymphocyte protein 4 | P16410 |
Registered trials
| Phase | Trials | Completed | Active | Stopped early |
|---|---|---|---|---|
| Phase not stated | 33 | 18 | 9 | 1 |
| Phase 1 | 204 | 97 | 48 | 50 |
| Phase 2 | 465 | 188 | 159 | 91 |
| Phase 3 | 67 | 37 | 23 | 3 |
| Phase 4 | 5 | 3 | 2 | 0 |
| All trials | 774 |
Who has held its approvals
| Company | Role | Years |
|---|---|---|
| Bristol Myers Squibb | Applicant and Lead sponsor of trials | 2003 to now |