Drug

Isocarboxazid

As of the edition of 20 October 2026, Isocarboxazid is a small molecule: marketed, first approved in 1982 (US); acts on MAOA and MAOB; no US protection is listed.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Marketed; latest approval 1982
Kind
Small molecule
Brand name
Marplan
First approved
1 January 1982 (US)
Approvals on record
1 in 1 region
Holder of the most recent approval
Lifsa Drugs
Withdrawn from market
1 January 1974 (in some regions)
Registered trials
1, 0 stopped early
Disease areas
Mental health; Nervous system

US protection

No US protection is listed.

The FDA registers list no drug-substance patent or exclusivity that counts for this drug.

This is the US only.

Targets

GeneProteinUniProt
MAOAAmine oxidase [flavin-containing] AP21397
MAOBAmine oxidase [flavin-containing] BP27338

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 11100
All trials1

Who has held its approvals

CompanyRoleYears
Lifsa DrugsAcquired holder2025 to now