Drug

Lasofoxifene

As of the edition of 20 October 2026, Lasofoxifene is a small molecule: withdrawn from the market in 2012; acts on ESR1 and ESR2.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Withdrawn from market, 2012
Kind
Small molecule
Withdrawn from market
27 February 2012 (in some regions)
Registered trials
9, 0 stopped early
Disease areas
Bones, joints and muscles; Cancer; Nutrition and metabolism; Skin and connective tissue; Mental health; Pregnancy and women's health

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Targets

GeneProteinUniProt
ESR1Estrogen receptorP03372
ESR2Estrogen receptor betaQ92731

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 26420
Phase 33210
All trials9

Who ran its trials

CompanyRoleYears
Ligand PharmaceuticalsLead sponsor of trials2001 to now