Patisiran sodium
As of the edition of 20 October 2026, Patisiran sodium is an oligonucleotide: marketed, first approved in 2018 (US); acts on TTR; US protection ends in 2035.
Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.
The drug
- Status
- Marketed; latest approval 2019
- Kind
- Oligonucleotide
- Brand name
- Onpattro
- First approved
- 10 August 2018 (US)
- Approvals on record
- 2 in 2 regions
- Holder of the most recent approval
- Alnylam Pharmaceuticals; 2 holders in all
US protection
US protection ends in 2035.
The last listed US drug-substance patent ends in 2035. The application that gives this date is held by Alnylam Pharmaceuticals.
This is the US only, and it is not the date generics or biosimilars can enter.
The exact date and the listings behind it
In the product4 listings count towards this date. The exact date and each listing are in the product.
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Target
| Gene | Protein | UniProt |
|---|---|---|
| TTR | Transthyretin | P02766 |
Who has held its approvals
| Company | Role | Years |
|---|---|---|
| Alnylam Pharmaceuticals | Originator and Applicant | 2018 to now |