Drug

Tesofensine

As of the edition of 20 October 2026, Tesofensine is a small molecule: went quiet in 2020; acts on SLC6A2, SLC6A3 and SLC6A4.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Went quiet, 2020
Kind
Small molecule
Registered trials
10, 0 stopped early
Disease areas
Nervous system; Nutrition and metabolism; Hormones; Mental health

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

6 company-target rows on route A because of this drug.

Companies on route A for this drug

In the product

6 company-target rows are on route A because of Tesofensine.

Targets

GeneProteinUniProt
SLC6A2Sodium-dependent noradrenaline transporterP23975
SLC6A4Sodium-dependent serotonin transporterP31645
SLC6A3Sodium-dependent dopamine transporterQ01959

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 2101000
All trials10

Who ran its trials

CompanyRoleYears
Boehringer IngelheimLead sponsor of trials2003 to now
NeuroSearch A/SLead sponsor of trials2006 to now
SanionaLead sponsor of trials2016 to now