Vinblastine
As of the edition of 20 October 2026, Vinblastine is a small molecule: marketed, first approved in 1961 (CH); acts on TUBB, TUBB1 and TUBB2A and 6 more.
Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.
The drug
- Status
- Marketed; latest approval 1998
- Kind
- Small molecule
- Brand name
- Velban
- First approved
- 23 May 1961 (CH)
- Approvals on record
- 6 in 6 regions
- Holder of the most recent approval
- Pfizer; 6 holders in all
- Registered trials
- 148, 17 stopped early
- Disease areas
- Cancer; Blood and lymph; Immune system; Urinary and reproductive; Pregnancy and women's health; Lungs and airways
US protection
No US approval on record.
With no US approval on record there are no listed US patents or exclusivities.
This is the US only.
Targets
| Gene | Protein | UniProt |
|---|---|---|
| TUBB4A | Tubulin beta-4A chain | P04350 |
| TUBB | Tubulin beta chain | P07437 |
| TUBB4B | Tubulin beta-4B chain | P68371 |
| TUBB3 | Tubulin beta-3 chain | Q13509 |
| TUBB2A | Tubulin beta-2A chain | Q13885 |
| TUBB8 | Tubulin beta-8 chain | Q3ZCM7 |
| TUBB6 | Tubulin beta-6 chain | Q9BUF5 |
| TUBB2B | Tubulin beta-2B chain | Q9BVA1 |
| TUBB1 | Tubulin beta-1 chain | Q9H4B7 |
Registered trials
| Phase | Trials | Completed | Active | Stopped early |
|---|---|---|---|---|
| Phase not stated | 8 | 5 | 0 | 0 |
| Phase 1 | 12 | 8 | 2 | 0 |
| Phase 2 | 79 | 41 | 15 | 12 |
| Phase 3 | 46 | 25 | 11 | 5 |
| Phase 4 | 3 | 2 | 1 | 0 |
| All trials | 148 |
Who has held its approvals
| Company | Role | Years |
|---|---|---|
| Pfizer | Applicant and Lead sponsor of trials | 1998 to now |
| Eli Lilly | Applicant | |
| Nippon Kayaku | Applicant |