CHRNA3
Neuronal acetylcholine receptor subunit alpha-3
As of the edition of 20 October 2026, CHRNA3 (neuronal acetylcholine receptor subunit alpha-3, UniProt P32297) has 6 drugs tested at it and 7 companies on the list, 3 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- P32297
- How well studied
- Drug target: an approved drug acts on it
- Where it sits in the cell
- In more than one place
- Solved structures
- 5
- Disease areas
- Nutrition and metabolism; Heart and blood vessels; Digestive system; Nervous system; Mental health; Lungs and airways; Immune system; Infections
- Registered trials of its drugs
- 41
Drugs at this target
| Status | Count |
|---|---|
| Marketed | 3 |
| Went quiet | 1 |
| Stopped | 2 |
| Total | 6 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Mecamylamine | Marketed | Phase 4 | none listed |
| Larazotide | Stopped | Phase 2 | none listed |
| Trimethaphan | Marketed | Phase 1 | none listed |
| ASM-024 | Stopped | Phase 2 | none listed |
| Simpinicline | Went quiet | Phase 2 | none listed |
| Pentolinium | Marketed | No phase stated | none listed |
6 of 6 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 3 |
| Engaged | 1 |
| Undetermined | 3 |
| Total on the list | 7 |
| Company | Route |
|---|---|
| Targacept | Route A |
| Amicus Therapeutics | Route A |
| Asmacure Ltée | Route A |
The other 4 companies at CHRNA3
In the product7 companies in all; 4 are not named here, and no score is.
See the 7 companies at CHRNA3, ranked, with the facts behind eachRequest access. Nothing is shown until you do.