DGAT1
Diacylglycerol O-acyltransferase 1
As of the edition of 20 October 2026, DGAT1 (diacylglycerol O-acyltransferase 1, UniProt O75907) has 5 drugs tested at it and 9 companies on the list, 4 on route A and 3 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- O75907
- How well studied
- Drug target: an approved drug acts on it
- Where it sits in the cell
- At a membrane
- Solved structures
- 5
- Disease areas
- Nutrition and metabolism; Heart and blood vessels; Digestive system; Hormones; Mental health; Nervous system; Cancer; Infections
- Registered trials of its drugs
- 49
Drugs at this target
| Status | Count |
|---|---|
| Marketed | 1 |
| Went quiet | 3 |
| Stopped | 1 |
| Total | 5 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Icosapent ethyl | Marketed | Phase 4 | none listed |
| Pradigastat | Stopped | Phase 3 | none listed |
| PF-04620110 | Went quiet | Phase 1 | none listed |
| AZD-7687 | Went quiet | Phase 1 | none listed |
| GSK3008356 | Went quiet | Phase 1 | none listed |
5 of 5 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 4 |
| Route B | 3 |
| Engaged | 1 |
| Undetermined | 1 |
| Total on the list | 9 |
| Company | Route |
|---|---|
| Novartis | Route A |
| Mochida Pharmaceutical | Route B |
| Recordati Industria Chimica e Farmaceutica | Route B |
The other 6 companies at DGAT1
In the product9 companies in all; 6 are not named here, and no score is.
See the 9 companies at DGAT1, ranked, with the facts behind eachRequest access. Nothing is shown until you do.