FOLH1
Glutamate carboxypeptidase 2
As of the edition of 20 October 2026, FOLH1 (glutamate carboxypeptidase 2, UniProt Q04609) has 27 drugs tested at it and 23 companies on the list, 5 on route A and 4 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- Q04609
- How well studied
- Drug target: an approved drug acts on it
- Where it sits in the cell
- At a membrane
- Solved structures
- 90
- Disease areas
- Cancer; Urinary and reproductive; Pregnancy and women's health; Digestive system; Skin and connective tissue; Chemically induced; Hormones; Injuries
- Registered trials of its drugs
- 171
Drugs at this target
| Status | Count |
|---|---|
| Marketed | 3 |
| Active | 7 |
| Went quiet | 7 |
| Stopped | 4 |
| Withdrawn from market | 1 |
| Status not established | 5 |
| Total | 27 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Vipivotide tetraxetan lutetium | Marketed | Phase 4 | Ends 2036 |
| Piflufolastat | Marketed | Phase 4 | Ends 2037 |
| Flotufolastat gallium | Marketed | Phase 4 | Ends 2038 |
| Flotufolastat | Active | Phase 4 | none listed |
| J591 177LU | Stopped | Phase 2 | none listed |
| Dcfbc | Went quiet | Phase 2 | none listed |
| AB-001 | Active | Phase 2 | none listed |
| Acapatamab | Stopped | Phase 2 | none listed |
| FPI-2265 | Active | Phase 2 | none listed |
| Iofolastat | Went quiet | Phase 1 | none listed |
| CB307 | Status not established | Phase 1 | none listed |
| MLN-2704 | Went quiet | Phase 2 | none listed |
12 of 27 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 5 |
| Route B | 4 |
| Engaged | 7 |
| Undetermined | 7 |
| Total on the list | 23 |
| Company | Route |
|---|---|
| Novartis | Route B |
| Merck & Co. | Route A |
| Blue Earth Diagnostics | Route B |
The other 20 companies at FOLH1
In the product23 companies in all; 20 are not named here, and no score is.
See the 23 companies at FOLH1, ranked, with the facts behind eachRequest access. Nothing is shown until you do.