MC4R
Melanocortin receptor 4
As of the edition of 20 October 2026, MC4R (melanocortin receptor 4, UniProt P32245) has 7 drugs tested at it and 9 companies on the list, 3 on route A and 1 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- P32245
- How well studied
- Drug target: an approved drug acts on it
- Where it sits in the cell
- At a membrane
- Solved structures
- 13
- Disease areas
- Nutrition and metabolism; Inherited and neonatal; Nervous system; Pregnancy and women's health; Urinary and reproductive; Eye; Hormones; Mental health
- Registered trials of its drugs
- 39
Drugs at this target
| Status | Count |
|---|---|
| Marketed | 2 |
| Active | 1 |
| Went quiet | 3 |
| Status not established | 1 |
| Total | 7 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Setmelanotide | Marketed | Phase 4 | Ends 2032 |
| Bremelanotide | Marketed | Phase 4 | none listed |
| LB54640 | Status not established | Phase 2 | none listed |
| MK0493 | Went quiet | Phase 2 | none listed |
| TCMCB07 | Active | Phase 2 | none listed |
| AZD2820 | Went quiet | Phase 1 | none listed |
| PF-00446687 | Went quiet | Phase 2 | none listed |
7 of 7 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 3 |
| Route B | 1 |
| Engaged | 1 |
| Undetermined | 4 |
| Total on the list | 9 |
| Company | Route |
|---|---|
| Rhythm Pharmaceuticals | Route B |
| Merck & Co. | Route A |
| Pfizer | Route A |
The other 6 companies at MC4R
In the product9 companies in all; 6 are not named here, and no score is.
See the 9 companies at MC4R, ranked, with the facts behind eachRequest access. Nothing is shown until you do.