NAE1
NEDD8-activating enzyme E1 regulatory subunit
As of the edition of 20 October 2026, NAE1 (NEDD8-activating enzyme E1 regulatory subunit, UniProt Q13564) has 2 drugs tested at it and 3 companies on the list, 1 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- Q13564
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- At a membrane
- Solved structures
- 9
- Disease areas
- Cancer; Blood and lymph; Immune system; Heart and blood vessels; Digestive system; Lungs and airways; Nervous system; Pregnancy and women's health
- Registered trials of its drugs
- 42
Drugs at this target
| Status | Count |
|---|---|
| Stopped | 2 |
| Total | 2 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Pevonedistat | Stopped | Phase 3 | none listed |
| TAS4464 | Stopped | Phase 1 | none listed |
2 of 2 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 1 |
| Undetermined | 2 |
| Total on the list | 3 |
| Company | Route |
|---|---|
| Taiho | Route A |
The other 2 companies at NAE1
In the product3 companies in all; 2 are not named here, and no score is.
See the 3 companies at NAE1, ranked, with the facts behind eachRequest access. Nothing is shown until you do.