NPC1L1
NPC1-like intracellular cholesterol transporter 1
As of the edition of 20 October 2026, NPC1L1 (NPC1-like intracellular cholesterol transporter 1, UniProt Q9UHC9) has 1 drug tested at it and 5 companies on the list, 0 on route A and 3 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- Q9UHC9
- How well studied
- Drug target: an approved drug acts on it
- Where it sits in the cell
- At a membrane
- Solved structures
- 7
- Disease areas
- Nutrition and metabolism; Heart and blood vessels; Hormones; Inherited and neonatal; Nervous system; Digestive system; Urinary and reproductive; Infections
- Registered trials of its drugs
- 275
Drugs at this target
| Status | Count |
|---|---|
| Marketed | 1 |
| Total | 1 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Ezetimibe | Marketed | Phase 4 | none listed |
1 of 1 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route B | 3 |
| Engaged | 2 |
| Total on the list | 5 |
| Company | Route |
|---|---|
| Merck & Co. | Route B |
| Organon | Route B |
| Daiichi Sankyo | Route B |
The other 2 companies at NPC1L1
In the product5 companies in all; 2 are not named here, and no score is.
See the 5 companies at NPC1L1, ranked, with the facts behind eachRequest access. Nothing is shown until you do.