Probatebeta
Target

OPRM1

Mu-type opioid receptor

As of the edition of 20 October 2026, OPRM1 (mu-type opioid receptor, UniProt P35372) has 64 drugs tested at it and 107 companies on the list, 5 on route A and 25 on route B.

Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.

The protein

UniProt
P35372
How well studied
Drug target: an approved drug acts on it
Where it sits in the cell
In more than one place
Solved structures
38
Disease areas
Mental health; Chemically induced; Nervous system; Cancer; Bones, joints and muscles; Lungs and airways; Digestive system; Urinary and reproductive
Registered trials of its drugs
3,106

Drugs at this target

StatusCount
Marketed42
Active4
Went quiet11
Stopped5
Withdrawn from market1
Status not established1
Total64
DrugStatusFurthest phaseUS protection
FentanylMarketedPhase 4none listed
MorphineMarketedPhase 4none listed
BuprenorphineMarketedPhase 4Ends 2028
NaltrexoneMarketedPhase 4none listed
RemifentanilMarketedPhase 4none listed
OxycodoneMarketedPhase 4none listed
NaloxoneMarketedPhase 4none listed
TramadolMarketedPhase 4none listed
MethadoneMarketedPhase 4none listed
SufentanilMarketedPhase 4none listed
HydromorphoneMarketedPhase 4none listed
TapentadolMarketedPhase 4Ends 2027

12 of 64 drugs, the most tested first.

Companies at this target

Where the company standsCompanies
Route A5
Route B25
Engaged36
Undetermined41
Total on the list107
Three companies on route A or B, with the route only
CompanyRoute
AstraZenecaRoute B
Merck & Co.Route B
RocheRoute B

The other 104 companies at OPRM1

In the product

107 companies in all; 104 are not named here, and no score is.

See the 107 companies at OPRM1, ranked, with the facts behind eachRequest access. Nothing is shown until you do.

More drugs at OPRM1

Other targets in mental health

Companies holding approvals at OPRM1