POLE
DNA polymerase epsilon catalytic subunit A
As of the edition of 20 October 2026, POLE (DNA polymerase epsilon catalytic subunit A, UniProt Q07864) has 2 drugs tested at it and 2 companies on the list, 0 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- Q07864
- How well studied
- Drug target: an approved drug acts on it
- Where it sits in the cell
- Inside the cell
- Solved structures
- 18
- Disease areas
- Cancer; Pregnancy and women's health; Urinary and reproductive; Lungs and airways
- Registered trials of its drugs
- 8
Drugs at this target
| Status | Count |
|---|---|
| Active | 2 |
| Total | 2 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| TAR-200 | Active | Phase 3 | none listed |
| FF-10832 | Active | Phase 2 | none listed |
2 of 2 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Engaged | 2 |
| Total on the list | 2 |