PRMT5
Protein arginine N-methyltransferase 5
As of the edition of 20 October 2026, PRMT5 (protein arginine N-methyltransferase 5, UniProt O14744) has 11 drugs tested at it and 8 companies on the list, 1 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- O14744
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- Inside the cell
- Solved structures
- 94
- Disease areas
- Cancer; Nervous system; Blood and lymph; Lungs and airways; Immune system; Digestive system; Skin and connective tissue; Hormones
- Registered trials of its drugs
- 27
Drugs at this target
| Status | Count |
|---|---|
| Active | 7 |
| Stopped | 2 |
| Status not established | 2 |
| Total | 11 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| BMS-986504 | Active | Phase 2 | none listed |
| Pemrametostat | Stopped | Phase 2 | none listed |
| TNG462 | Active | Phase 2 | none listed |
| AZD3470 | Active | Phase 2 | none listed |
| JBI-778 | Active | Phase 2 | none listed |
| MRTX1719 | Active | Phase 1 | none listed |
| Onametostat | Active | Phase 1 | none listed |
| PRT543 | Status not established | Phase 1 | none listed |
| PRT811 | Status not established | Phase 1 | none listed |
| TNG456 | Active | Phase 2 | none listed |
| TNG908 | Stopped | Phase 2 | none listed |
11 of 11 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 1 |
| Engaged | 6 |
| Undetermined | 1 |
| Total on the list | 8 |
| Company | Route |
|---|---|
| GSK | Route A |
The other 7 companies at PRMT5
In the product8 companies in all; 7 are not named here, and no score is.
See the 8 companies at PRMT5, ranked, with the facts behind eachRequest access. Nothing is shown until you do.