REN
Renin
As of the edition of 20 October 2026, REN (renin, UniProt P00797) has 5 drugs tested at it and 8 companies on the list, 4 on route A and 1 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- P00797
- How well studied
- Drug target: an approved drug acts on it
- Where it sits in the cell
- In more than one place
- Solved structures
- 91
- Disease areas
- Heart and blood vessels; Nutrition and metabolism; Hormones; Pregnancy and women's health; Urinary and reproductive; Immune system; Bones, joints and muscles; Cancer
- Registered trials of its drugs
- 135
Drugs at this target
| Status | Count |
|---|---|
| Marketed | 1 |
| Went quiet | 3 |
| Stopped | 1 |
| Total | 5 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Aliskiren | Marketed | Phase 4 | none listed |
| Sitokiren | Stopped | Phase 3 | none listed |
| Imarikiren | Went quiet | Phase 2 | none listed |
| SPP635 | Went quiet | Phase 2 | none listed |
| VTP-27999 | Went quiet | Phase 1 | none listed |
5 of 5 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 4 |
| Route B | 1 |
| Engaged | 1 |
| Undetermined | 2 |
| Total on the list | 8 |
| Company | Route |
|---|---|
| Lxo Ireland Designated Activity | Route B |
| Pharma Biotherapeutics | Route A |
| Takeda | Route A |
The other 5 companies at REN
In the product8 companies in all; 5 are not named here, and no score is.
See the 8 companies at REN, ranked, with the facts behind eachRequest access. Nothing is shown until you do.