Probatebeta
Target

ADRA1B

Alpha-1B adrenergic receptor

As of the edition of 20 October 2026, ADRA1B (alpha-1B adrenergic receptor, UniProt P35368) has 39 drugs tested at it and 32 companies on the list, 3 on route A and 11 on route B.

Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.

The protein

UniProt
P35368
How well studied
Drug target: an approved drug acts on it
Where it sits in the cell
In more than one place
Disease areas
Heart and blood vessels; Urinary and reproductive; Nervous system; Pregnancy and women's health; Lungs and airways; Mental health; Infections; Digestive system
Registered trials of its drugs
1,248

Drugs at this target

StatusCount
Marketed33
Active2
Went quiet2
Withdrawn from market1
Status not established1
Total39
DrugStatusFurthest phaseUS protection
EpinephrineMarketedPhase 4none listed
NorepinephrineMarketedPhase 4none listed
PhenylephrineMarketedPhase 4none listed
TamsulosinMarketedPhase 4none listed
CarvedilolMarketedPhase 4none listed
MidodrineMarketedPhase 4none listed
OxymetazolineMarketedPhase 4none listed
EphedrineMarketedPhase 4none listed
PrazosinMarketedPhase 4none listed
AlfuzosinMarketedPhase 4none listed
DoxazosinMarketedPhase 4none listed
LabetalolMarketedPhase 4none listed

12 of 39 drugs, the most tested first.

Companies at this target

Where the company standsCompanies
Route A3
Route B11
Engaged15
Undetermined3
Total on the list32
Three companies on route A or B, with the route only
CompanyRoute
Merck & Co.Route B
PfizerRoute B
GSKRoute B

The other 29 companies at ADRA1B

In the product

32 companies in all; 29 are not named here, and no score is.

See the 32 companies at ADRA1B, ranked, with the facts behind eachRequest access. Nothing is shown until you do.

More drugs at ADRA1B

Other targets in heart and blood vessels

Companies holding approvals at ADRA1B