TLR4
Toll-like receptor 4
As of the edition of 20 October 2026, TLR4 (toll-like receptor 4, UniProt O00206) has 5 drugs tested at it and 7 companies on the list, 3 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- O00206
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- In more than one place
- Solved structures
- 15
- Disease areas
- Infections; Lungs and airways; Digestive system; Immune system; Blood and lymph; Bones, joints and muscles; Cancer; Ear, nose and throat
- Registered trials of its drugs
- 16
Drugs at this target
| Status | Count |
|---|---|
| Active | 1 |
| Went quiet | 1 |
| Stopped | 2 |
| Status not established | 1 |
| Total | 5 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Eritoran | Went quiet | Phase 3 | none listed |
| JKB-122 | Stopped | Phase 2 | none listed |
| Paridiprubart | Active | Phase 3 | none listed |
| Resatorvid | Stopped | Phase 3 | none listed |
| INI-2004 | Status not established | Phase 1 | none listed |
5 of 5 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 3 |
| Engaged | 1 |
| Undetermined | 3 |
| Total on the list | 7 |
| Company | Route |
|---|---|
| Edesa Biotech | Route A |
| Takeda | Route A |
| TaiwanJ Pharmaceuticals | Route A |
The other 4 companies at TLR4
In the product7 companies in all; 4 are not named here, and no score is.
See the 7 companies at TLR4, ranked, with the facts behind eachRequest access. Nothing is shown until you do.