UBA3
NEDD8-activating enzyme E1 catalytic subunit
As of the edition of 20 October 2026, UBA3 (NEDD8-activating enzyme E1 catalytic subunit, UniProt Q8TBC4) has 1 drug tested at it and 2 companies on the list, 0 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- Q8TBC4
- How well studied
- Chemical tools exist; no approved drug acts on it
- Solved structures
- 12
- Disease areas
- Cancer; Blood and lymph; Immune system; Digestive system; Heart and blood vessels; Lungs and airways; Nervous system; Pregnancy and women's health
- Registered trials of its drugs
- 41
Drugs at this target
| Status | Count |
|---|---|
| Stopped | 1 |
| Total | 1 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Pevonedistat | Stopped | Phase 3 | none listed |
1 of 1 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Undetermined | 2 |
| Total on the list | 2 |