US protection ending in 2031: Nutrition and metabolism
As of the edition of 20 October 2026, 24 drugs have US protection that ends in 2031 in nutrition and metabolism; 15 of them have at least one company on route B because of it.
Sources: FDA Orange Book and Purple Book, other approval registers.
24 drugs
| Drug | US protection | Status | Holder | Target | Route B rows |
|---|---|---|---|---|---|
| Bosutinib | Ends 2031 (exclusivity) | Marketed | Pfizer | ABL1 | 1 |
| Cabotegravir | Ends 2031 (patent) | Marketed | GSK | 0 | |
| Cerliponase alfa | Ends 2031 (orphan exclusivity) | Marketed | Amicus Therapeutics | 0 | |
| Cipepofol | Ends 2031 (exclusivity) | Marketed | Haisco-USA Pharmaceuticals | 0 | |
| Daclatasvir | Ends 2031 (patent) | Marketed | Bristol Myers Squibb | 0 | |
| Dolutegravir | Ends 2031 (patent) | Marketed | GSK | 0 | |
| Elafibranor | Ends 2031 (exclusivity) | Marketed | Ipsen | PPARA, PPARD | 2 |
| Elbasvir | Ends 2031 (patent) | Marketed | Merck & Co. | 0 | |
| Ertugliflozin | Ends 2031 (patent) | Marketed | Merck & Co. | SLC5A2 | 1 |
| Etelcalcetide | Ends 2031 (patent) | Marketed | Amgen | CASR | 1 |
| Iberdomide | Ends 2031 (exclusivity) | Marketed | Bristol Myers Squibb | CRBN, CUL4A, DDB1 | 0 |
| Inotersen | Ends 2031 (patent) | Marketed | Akcea Therapeutics | TTR | 1 |
| Lemborexant | Ends 2031 (patent) | Marketed | Eisai | HCRTR1, HCRTR2 | 2 |
| Letrozole | Ends 2031 (patent) | Marketed | Novartis | CYP19A1 | 1 |
| Levacetylleucine | Ends 2031 (exclusivity) | Marketed | IntraBio | F9 | 1 |
| Mavorixafor | Ends 2031 (exclusivity) | Marketed | X4 Pharmaceuticals | CXCR4 | 2 |
| Nitrous acid | Ends 2031 (patent) | Marketed | Hope Biosciences | 0 | |
| Nivolumab | Ends 2031 (orphan exclusivity) | Marketed | Bristol Myers Squibb | PDCD1 | 2 |
| Pembrolizumab | Ends 2031 (orphan exclusivity) | Marketed | Merck & Co. | PDCD1 | 1 |
| Pomalidomide | Ends 2031 (patent) | Marketed | Bristol Myers Squibb | CRBN | 0 |
| Romosozumab | Ends 2031 (computed from the first US licence) | Marketed | Amgen | SOST | 2 |
| Rucaparib | Ends 2031 (patent) | Marketed | pharmaand | PARP1, PARP2, PARP3 | 5 |
| Seladelpar | Ends 2031 (exclusivity) | Marketed | Gilead Sciences | PPARD | 1 |
| Vortioxetine | Ends 2031 (patent) | Marketed | Takeda | HTR1A, HTR3A, SLC6A4 | 5 |
Listed by name. A route B row is one company at one target; for a drug with one target that is the number of companies. US protection is the US only, and it is not the date generics or biosimilars can enter.
Which companies are on route B in 2031 in nutrition and metabolism
In the product15 of these 24 drugs have at least one company on route B. Which companies, and their scores, are in the product.
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