US protection ending in 2033: Bones, joints and muscles
As of the edition of 20 October 2026, 10 drugs have US protection that ends in 2033 in bones, joints and muscles; 8 of them have at least one company on route B because of it.
Sources: FDA Orange Book and Purple Book, other approval registers.
10 drugs
| Drug | US protection | Status | Holder | Target | Route B rows |
|---|---|---|---|---|---|
| Alpelisib | Ends 2033 (patent) | Marketed | Novartis | PIK3CA | 1 |
| Anifrolumab | Ends 2033 (computed from the first US licence) | Marketed | AstraZeneca | IFNAR1 | 1 |
| Binimetinib | Ends 2033 (patent) | Marketed | Pfizer | MAP2K1, MAP2K2 | 6 |
| Cravacitinib | Ends 2033 (patent) | Marketed | Bristol Myers Squibb | TYK2 | 1 |
| Efgartigimod alfa | Ends 2033 (computed from the first US licence) | Marketed | argenx | FCGRT | 1 |
| Erdafitinib | Ends 2033 (patent) | Marketed | Johnson & Johnson | FGFR1, FGFR2, FGFR3 | 4 |
| Lonapegsomatropin | Ends 2033 (computed from the first US licence) | Marketed | Ascendis Pharma A/S | GHR | 1 |
| Omaveloxolone | Ends 2033 (patent) | Marketed | Biogen | NFE2L2 | 1 |
| Streptococcus pneumoniae polysaccharide conjugated to corynebacterium diphtheriae crm197 | Ends 2033 (reference-product exclusivity) | Marketed | Merck & Co. | 0 | |
| Tozinameran | Ends 2033 (computed from the first US licence) | Marketed | BioNTech Manufacturing GmbH | 0 |
Listed by name. A route B row is one company at one target; for a drug with one target that is the number of companies. US protection is the US only, and it is not the date generics or biosimilars can enter.
Which companies are on route B in 2033 in bones, joints and muscles
In the product8 of these 10 drugs have at least one company on route B. Which companies, and their scores, are in the product.
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