Drug

CI-1040

As of the edition of 20 October 2026, CI-1040 is a small molecule: went quiet in 2003; acts on MAP2K1 and MAP2K2.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Went quiet, 2003
Kind
Small molecule
Registered trials
2, 0 stopped early
Disease areas
Cancer; Digestive system; Hormones; Lungs and airways; Skin and connective tissue

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

2 company-target rows on route B because of this drug.

Companies on route B for this drug

In the product

2 company-target rows are on route B because of CI-1040.

Targets

GeneProteinUniProt
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2P36507
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1Q02750

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 22200
All trials2

Who ran its trials

CompanyRoleYears
PfizerLead sponsor of trials2002 to now