Drug

Refametinib

As of the edition of 20 October 2026, Refametinib is a small molecule: went quiet in 2017; acts on MAP2K1 and MAP2K2.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Went quiet, 2017
Kind
Small molecule
Registered trials
11, 1 stopped early
Disease areas
Cancer; Digestive system; Hormones

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

2 company-target rows on route A because of this drug.

Companies on route A for this drug

In the product

2 company-target rows are on route A because of Refametinib.

Targets

GeneProteinUniProt
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2P36507
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1Q02750

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 16501
Phase 25500
All trials11

Who ran its trials

CompanyRoleYears
BayerLead sponsor of trials2007 to now