Drug

Evt-101 free base

As of the edition of 20 October 2026, Evt-101 free base is a small molecule: stopped in 2011; acts on GRIN1 and GRIN2B.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Stopped, 2011
Kind
Small molecule
Registered trials
2, 1 stopped early
Disease areas
Mental health

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

2 company-target rows on route B and 2 company-target rows on route A because of this drug.

Companies on route B for this drug

In the product

2 company-target rows are on route B because of Evt-101 free base.

Companies on route A for this drug

In the product

2 company-target rows are on route A because of Evt-101 free base.

Targets

GeneProteinUniProt
GRIN1Glutamate receptor ionotropic, NMDA 1Q05586
GRIN2BGlutamate receptor ionotropic, NMDA 2BQ13224

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 11100
Phase 21001
All trials2

Who ran its trials

CompanyRoleYears
Evotec NeurosciencesLead sponsor of trials2007 to now
Johnson & JohnsonLead sponsor of trials2010 to now