Drug

IRX-4204

As of the edition of 20 October 2026, IRX-4204 is a small molecule: stopped in 2025; acts on RXRA, RXRB and RXRG.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Stopped, 2025
Kind
Small molecule
Registered trials
5, 2 stopped early
Disease areas
Cancer; Lungs and airways; Nervous system

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

6 company-target rows on route A because of this drug.

Companies on route A for this drug

In the product

6 company-target rows are on route A because of IRX-4204.

Targets

GeneProteinUniProt
RXRARetinoic acid receptor RXR-alphaP19793
RXRBRetinoic acid receptor RXR-betaP28702
RXRGRetinoic acid receptor RXR-gammaP48443

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 13102
Phase 22100
All trials5

Who ran its trials

CompanyRoleYears
NuRx PharmaceuticalsLead sponsor of trials2009 to now
Io TherapeuticsLead sponsor of trials2011 to now