Drug

Motexafin gadolinium

As of the edition of 20 October 2026, Motexafin gadolinium is a small molecule: stopped in 2014; acts on RRM1, RRM2 and RRM2B and 1 more.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Stopped, 2014
Kind
Small molecule
Registered trials
36, 8 stopped early
Disease areas
Cancer; Lungs and airways; Nervous system; Blood and lymph; Immune system; Urinary and reproductive

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Companies that need a new molecule because of this drug

2 company-target rows on route A because of this drug.

Companies on route A for this drug

In the product

2 company-target rows are on route A because of Motexafin gadolinium.

Targets

GeneProteinUniProt
RRM1Ribonucleoside-diphosphate reductase large subunitP23921
RRM2Ribonucleoside-diphosphate reductase subunit M2P31350
TXNRD1Thioredoxin reductase 1, cytoplasmicQ16881
RRM2BRibonucleoside-diphosphate reductase subunit M2 BQ7LG56

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase not stated3100
Phase 1161402
Phase 216806
Phase 31100
All trials36

Who ran its trials

CompanyRoleYears
AbbVieLead sponsor of trials2005 to now