Drug

Triapine

As of the edition of 20 October 2026, Triapine is a small molecule: stopped in 2013; acts on RRM1 and RRM2B.

Sources: FDA Orange Book and Purple Book, other approval registers, ClinicalTrials.gov, ChEMBL.

The drug

Status
Stopped, 2013
Kind
Small molecule
Registered trials
34, 1 stopped early
Disease areas
Cancer; Urinary and reproductive; Blood and lymph; Pregnancy and women's health; Digestive system; Hormones

US protection

No US approval on record.

With no US approval on record there are no listed US patents or exclusivities.

This is the US only.

Targets

GeneProteinUniProt
RRM1Ribonucleoside-diphosphate reductase large subunitP23921
RRM2BRibonucleoside-diphosphate reductase subunit M2 BQ7LG56

Registered trials

PhaseTrialsCompletedActiveStopped early
Phase 1181350
Phase 2151311
Phase 31010
All trials34

Who ran its trials

CompanyRoleYears
Vion PharmaceuticalsLead sponsor of trials1998 to now
Cancer TherapeuticsLead sponsor of trials2004 to now