Target

ALDH5A1

Succinate-semialdehyde dehydrogenase, mitochondrial

As of the edition of 20 October 2026, ALDH5A1 (succinate-semialdehyde dehydrogenase, mitochondrial, UniProt P51649) has 1 drug tested at it and 5 companies on the list, 0 on route A and 2 on route B.

Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.

The protein

UniProt
P51649
How well studied
Drug target: an approved drug acts on it
Where it sits in the cell
Inside the cell
Solved structures
5
Disease areas
Mental health; Nervous system; Cancer; Blood and lymph; Urinary and reproductive; Immune system; Pregnancy and women's health; Infections
Registered trials of its drugs
270

Drugs at this target

StatusCount
Marketed1
Total1
DrugStatusFurthest phaseUS protection
Valproic acidMarketedPhase 4none listed

1 of 1 drugs, the most tested first.

Companies at this target

Where the company standsCompanies
Route B2
Engaged3
Total on the list5
Three companies on route A or B, with the route only
CompanyRoute
SanofiRoute B
KowaRoute B

The other 3 companies at ALDH5A1

In the product

5 companies in all; 3 are not named here, and no score is.

See the 5 companies at ALDH5A1, ranked, with the facts behind eachRequest access. Nothing is shown until you do.