BACE1
Beta-secretase 1
As of the edition of 20 October 2026, BACE1 (beta-secretase 1, UniProt P56817) has 12 drugs tested at it and 9 companies on the list, 9 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- P56817
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- In more than one place
- Solved structures
- 431
- Disease areas
- Mental health; Nervous system; Blood and lymph; Cancer; Immune system; Pregnancy and women's health; Urinary and reproductive
- Registered trials of its drugs
- 74
Drugs at this target
| Status | Count |
|---|---|
| Went quiet | 4 |
| Stopped | 8 |
| Total | 12 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Lanabecestat | Stopped | Phase 3 | none listed |
| Atabecestat | Stopped | Phase 3 | none listed |
| Elenbecestat | Stopped | Phase 3 | none listed |
| LY-2886721 | Stopped | Phase 2 | none listed |
| LY3202626 | Went quiet | Phase 2 | none listed |
| Verubecestat | Stopped | Phase 3 | none listed |
| BI 1181181 | Stopped | Phase 1 | none listed |
| CNP520 | Stopped | Phase 3 | none listed |
| RO5508887 | Went quiet | Phase 1 | none listed |
| AZD-3839 | Went quiet | Phase 1 | none listed |
| HPP854 | Stopped | Phase 1 | none listed |
| LY-2811376 | Went quiet | Phase 1 | none listed |
12 of 12 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 9 |
| Total on the list | 9 |
| Company | Route |
|---|---|
| Eli Lilly | Route A |
| Eisai | Route A |
| Merck & Co. | Route A |
The other 6 companies at BACE1
In the product9 companies in all; 6 are not named here, and no score is.
See the 9 companies at BACE1, ranked, with the facts behind eachRequest access. Nothing is shown until you do.