CHEK1
Serine/threonine-protein kinase Chk1
As of the edition of 20 October 2026, CHEK1 (serine/threonine-protein kinase Chk1, UniProt O14757) has 12 drugs tested at it and 10 companies on the list, 7 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- O14757
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- Inside the cell
- Solved structures
- 168
- Disease areas
- Cancer; Blood and lymph; Immune system; Lungs and airways; Digestive system; Hormones; Urinary and reproductive; Pregnancy and women's health
- Registered trials of its drugs
- 64
Drugs at this target
| Status | Count |
|---|---|
| Active | 2 |
| Went quiet | 5 |
| Stopped | 5 |
| Total | 12 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| UCN-01 | Stopped | Phase 2 | none listed |
| Prexasertib | Active | Phase 2 | none listed |
| Rabusertib | Went quiet | Phase 2 | none listed |
| AZD-7762 | Stopped | Phase 1 | none listed |
| SCH-900776 | Went quiet | Phase 2 | none listed |
| PEP07 | Active | Phase 1 | none listed |
| SRA-737 | Went quiet | Phase 2 | none listed |
| XL-844 | Stopped | Phase 1 | none listed |
| BBI-355 | Stopped | Phase 1 | none listed |
| PF-00477736 | Stopped | Phase 1 | none listed |
| RG-7602 | Went quiet | Phase 1 | none listed |
| RG-7741 | Went quiet | Phase 1 | none listed |
12 of 12 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 7 |
| Engaged | 3 |
| Total on the list | 10 |
| Company | Route |
|---|---|
| Pfizer | Route A |
| Merck & Co. | Route A |
| AstraZeneca | Route A |
The other 7 companies at CHEK1
In the product10 companies in all; 7 are not named here, and no score is.
See the 10 companies at CHEK1, ranked, with the facts behind eachRequest access. Nothing is shown until you do.