DHFR
Dihydrofolate reductase
As of the edition of 20 October 2026, DHFR (dihydrofolate reductase, UniProt P00374) has 7 drugs tested at it and 28 companies on the list, 2 on route A and 7 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- P00374
- How well studied
- Drug target: an approved drug acts on it
- Where it sits in the cell
- Inside the cell
- Solved structures
- 89
- Disease areas
- Cancer; Immune system; Lungs and airways; Blood and lymph; Skin and connective tissue; Bones, joints and muscles; Infections; Nervous system
- Registered trials of its drugs
- 2,222
Drugs at this target
| Status | Count |
|---|---|
| Marketed | 3 |
| Went quiet | 2 |
| Stopped | 2 |
| Total | 7 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Methotrexate | Marketed | Phase 4 | none listed |
| Pemetrexed | Marketed | Phase 4 | none listed |
| Pralatrexate | Marketed | Phase 4 | none listed |
| Talotrexin | Stopped | Phase 2 | none listed |
| Aminopterin | Stopped | Phase 2 | none listed |
| CH-1504 | Went quiet | Phase 2 | none listed |
| Piritrexim | Went quiet | Phase 2 | none listed |
7 of 7 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 2 |
| Route B | 7 |
| Engaged | 19 |
| Total on the list | 28 |
The other 25 companies at DHFR
In the product28 companies in all; 25 are not named here, and no score is.
See the 28 companies at DHFR, ranked, with the facts behind eachRequest access. Nothing is shown until you do.