DHODH
Dihydroorotate dehydrogenase
As of the edition of 20 October 2026, DHODH (dihydroorotate dehydrogenase, UniProt Q02127) has 13 drugs tested at it and 12 companies on the list, 4 on route A and 1 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- Q02127
- How well studied
- Drug target: an approved drug acts on it
- Where it sits in the cell
- At a membrane
- Solved structures
- 106
- Disease areas
- Immune system; Nervous system; Skin and connective tissue; Cancer; Bones, joints and muscles; Blood and lymph; Lungs and airways; Infections
- Registered trials of its drugs
- 144
Drugs at this target
| Status | Count |
|---|---|
| Marketed | 2 |
| Active | 5 |
| Stopped | 6 |
| Total | 13 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Leflunomide | Marketed | Phase 4 | none listed |
| Teriflunomide | Marketed | Phase 4 | none listed |
| Vidofludimus | Active | Phase 3 | none listed |
| Emvododstat | Stopped | Phase 3 | none listed |
| ASLAN-003 | Active | Phase 2 | none listed |
| Brequinar | Stopped | Phase 2 | none listed |
| BAY 2402234 | Stopped | Phase 1 | none listed |
| JNJ-74856665 | Active | Phase 1 | none listed |
| RP7214 | Stopped | Phase 2 | none listed |
| AG-636 | Stopped | Phase 1 | none listed |
| JBZ-001 | Active | Phase 1 | none listed |
| KIO-101 | Stopped | Phase 2 | none listed |
12 of 13 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 4 |
| Route B | 1 |
| Engaged | 6 |
| Undetermined | 1 |
| Total on the list | 12 |
| Company | Route |
|---|---|
| Zentiva k.s | Route B |
| PTC Therapeutics | Route A |
| Bayer | Route A |
The other 9 companies at DHODH
In the product12 companies in all; 9 are not named here, and no score is.
See the 12 companies at DHODH, ranked, with the facts behind eachRequest access. Nothing is shown until you do.