GRM2
Metabotropic glutamate receptor 2
As of the edition of 20 October 2026, GRM2 (metabotropic glutamate receptor 2, UniProt Q14416) has 9 drugs tested at it and 7 companies on the list, 6 on route A and 0 on route B.
Sources: UniProt, ClinicalTrials.gov, ChEMBL, FDA Orange Book and Purple Book, Pharos.
The protein
- UniProt
- Q14416
- How well studied
- Chemical tools exist; no approved drug acts on it
- Where it sits in the cell
- In more than one place
- Solved structures
- 31
- Disease areas
- Mental health; Nervous system; Digestive system
- Registered trials of its drugs
- 52
Drugs at this target
| Status | Count |
|---|---|
| Active | 1 |
| Went quiet | 7 |
| Stopped | 1 |
| Total | 9 |
| Drug | Status | Furthest phase | US protection |
|---|---|---|---|
| Pomaglumetad methionil anhydrous | Stopped | Phase 3 | none listed |
| JNJ-40411813 | Active | Phase 2 | none listed |
| AZD 8529 | Went quiet | Phase 2 | none listed |
| Decoglurant | Went quiet | Phase 2 | none listed |
| LY2979165 | Went quiet | Phase 1 | none listed |
| TS-134 | Went quiet | Phase 1 | none listed |
| LY404039 | Went quiet | Phase 1 | none listed |
| MGS-0210 | Went quiet | Phase 1 | none listed |
| LY2969822 | Went quiet | Phase 1 | none listed |
9 of 9 drugs, the most tested first.
Companies at this target
| Where the company stands | Companies |
|---|---|
| Route A | 6 |
| Engaged | 1 |
| Total on the list | 7 |
| Company | Route |
|---|---|
| Denovo Biopharma | Route A |
| Eli Lilly | Route A |
| Roche | Route A |
The other 4 companies at GRM2
In the product7 companies in all; 4 are not named here, and no score is.
See the 7 companies at GRM2, ranked, with the facts behind eachRequest access. Nothing is shown until you do.