US protection ending in 2026: Digestive system
As of the edition of 20 October 2026, 20 drugs have US protection that ends (or has ended) in 2026 in digestive system; 10 of them have at least one company on route B because of it.
Sources: FDA Orange Book and Purple Book, other approval registers.
20 drugs
| Drug | US protection | Status | Holder | Target | Route B rows |
|---|---|---|---|---|---|
| Afamelanotide | Ended 2026 (exclusivity) | Marketed | Clinuvel | MC1R | 1 |
| Belinostat | Ended 2026 (patent) | Marketed | Acrotech Biopharma | 0 | |
| Darunavir | Ends 2026 (patent) | Marketed | Johnson & Johnson | 0 | |
| Dasatinib anhydrous | Ended 2026 (exclusivity) | Marketed | ABL1, BLK, FGR | 12 | |
| Dulaglutide | Ended 2026 (computed from the first US licence) | Marketed | Eli Lilly | GLP1R | 0 |
| Elvitegravir | Ends 2026 (patent) | Marketed | Gilead Sciences | 0 | |
| Eribulin | Ended 2026 (exclusivity) | Marketed | Eisai | TUBB, TUBB1, TUBB2A | 9 |
| Escitalopram | Ended 2026 (exclusivity) | Marketed | AbbVie | SLC6A4 | 4 |
| Lacosamide | Ended 2026 (exclusivity) | Marketed | UCB | SCN10A, SCN11A, SCN1A | 0 |
| Linagliptin | Ends 2026 (exclusivity) | Marketed | Boehringer Ingelheim | DPP4 | 1 |
| Metreleptin | Ended 2026 (computed from the first US licence) | Marketed | Chiesi Farmaceutici | LEPR | 0 |
| Onabotulinumtoxina | Ended 2026 (orphan exclusivity) | Marketed | AbbVie | SNAP25 | 0 |
| Pasireotide | Ends 2026 (patent) | Marketed | Recordati Rare Diseases | SSTR2, SSTR3, SSTR5 | 0 |
| Ramucirumab | Ended 2026 (orphan exclusivity) | Marketed | Eli Lilly | KDR | 1 |
| Siltuximab | Ended 2026 (computed from the first US licence) | Marketed | Recordati Rare Diseases | IL6 | 2 |
| Sitagliptin | Ends 2026 (patent) | Marketed | Merck & Co. | DPP4 | 1 |
| Teduglutide | Ended 2026 (exclusivity) | Marketed | Takeda | GLP2R | 1 |
| Tolvaptan | Ended 2026 (patent) | Marketed | Otsuka | AVPR2 | 0 |
| Triclabendazole | Ended 2026 (exclusivity) | Marketed | Novartis | 0 | |
| Vedolizumab | Ended 2026 (computed from the first US licence) | Marketed | Takeda | ITGA4 | 1 |
Listed by name. A route B row is one company at one target; for a drug with one target that is the number of companies. US protection is the US only, and it is not the date generics or biosimilars can enter.
Which companies are on route B in 2026 in digestive system
In the product10 of these 20 drugs have at least one company on route B. Which companies, and their scores, are in the product.
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