US protection ending in 2028: Chemically induced
As of the edition of 20 October 2026, 14 drugs have US protection that ends in 2028 in chemically induced; 14 of them have at least one company on route B because of it.
Sources: FDA Orange Book and Purple Book, other approval registers.
14 drugs
| Drug | US protection | Status | Holder | Target | Route B rows |
|---|---|---|---|---|---|
| Adalimumab | Ends 2028 (orphan exclusivity) | Marketed | AbbVie | TNF | 4 |
| Apremilast | Ends 2028 (patent) | Marketed | Amgen | PDE4A, PDE4B, PDE4C | 4 |
| Brexpiprazole | Ends 2028 (patent) | Marketed | Otsuka | DRD2, HTR1A, HTR2A | 2 |
| Buprenorphine | Ends 2028 (exclusivity) | Marketed | Indivior | OPRK1, OPRM1 | 9 |
| Daratumumab | Ends 2028 (orphan exclusivity) | Marketed | Johnson & Johnson | CD38 | 1 |
| Empagliflozin | Ends 2028 (patent) | Marketed | Boehringer Ingelheim | SLC5A2 | 1 |
| Esketamine | Ends 2028 (exclusivity) | Marketed | Johnson & Johnson | GRIN1, GRIN2A, GRIN2B | 5 |
| Gepirone | Ends 2028 (exclusivity) | Marketed | Fabre Kramer Pharmaceuticals | HTR1A | 1 |
| Oxybate | Ends 2028 (exclusivity) | Marketed | GABBR1, GABBR2 | 2 | |
| Rilonacept | Ends 2028 (orphan exclusivity) | Marketed | Kiniksa Pharmaceuticals | IL1B | 1 |
| Rituximab | Ends 2028 (orphan exclusivity) | Marketed | Roche | MS4A1 | 1 |
| Safinamide | Ends 2028 (patent) | Marketed | Supernus Pharmaceuticals | MAOB | 1 |
| Tacrolimus anhydrous | Ends 2028 (exclusivity) | Marketed | Astellas | FKBP1A | 3 |
| Tofacitinib | Ends 2028 (exclusivity) | Marketed | Pfizer | JAK1, JAK2, JAK3 | 2 |
Listed by name. A route B row is one company at one target; for a drug with one target that is the number of companies. US protection is the US only, and it is not the date generics or biosimilars can enter.
Which companies are on route B in 2028 in chemically induced
In the product14 of these 14 drugs have at least one company on route B. Which companies, and their scores, are in the product.
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